What is the normal level of HE4?

Results. HE4 reference limit for healthy patients equals 85 pmol/l, which becomes 73 pmol/l and 93 pmol/l for pre and postmenopausal subgroups, respectively. There is a statistically significant correlation between HE4 serum level and smoking ( ) and there is no correlation with creatinine.

What is HE4 blood test for?

The HE4 test measures the amount of human epididymis protein 4 in the blood. Significantly elevated concentrations of HE4 are frequently present in the blood of a woman who has epithelial ovarian cancer.

What is considered a high HE4 level?

When a woman is in menopause age and if the HE4 level is <147 pmol/l, and what is very similar to the internationally accepted value of <140 pmol/l, there is a 9% chance of cancer. If HE4 is higher than 147 pmol/l and eGFR is not below 48 ml/min/1.73m2, 95% of cases are probably malignant.

What does CA125 blood test show?

A CA 125 test measures the amount of the protein CA 125 (cancer antigen 125) in your blood. A CA 125 test may be used to monitor certain cancers during and after treatment. In some cases, a CA 125 test may be used to look for early signs of ovarian cancer in people with a very high risk of the disease.

Why is afp high?

High levels of AFP can be a sign of liver cancer or cancer of the ovaries or testicles, as well as noncancerous liver diseases such as cirrhosis and hepatitis. High AFP levels don’t always mean cancer, and normal levels don’t always rule out cancer.

How accurate is HE4?

The combination of HE4 and CA125 showed sensitivity 75.8%, specificity 93.5%, and accuracy 85.7%.

Why is AFP high?

How do I lower my AFP?

Iron reduction therapy significantly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL ( for each).

How sensitive is CA 125?

The sensitivity of CA 125 in distinguishing between benign and malignant masses ranges between 61% and 90%, while specificity ranges between 35% and 91%. The wide variation in these values is due to different inclusion criteria for premenopausal women across studies.

What does HE4 stand for in cancer test?

Human epididymis protein 4 (HE4) is a protein that is produced by most, but not all, epithelial ovarian cancer cells. This makes the test useful as a tumor marker in specific circumstances. The HE4 test measures the amount of human epididymis protein 4 in the blood.

Where is HE4 found in the human body?

HE4 has been reported to be expressed in a number of normal tissues, including epithelia of respiratory and reproductive tissues. 9,10 Elevated levels were found in several tumor cell lines, including ovarian, lung, colon, and breast cancer.

When to use the HE4 assay for ovarian cancer?

The assay is to be used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical methods used for monitoring ovarian cancer.

Is it normal to have a ca 125 level of HE4?

But more testing would be needed to be sure, because CA 125 levels can also be increased by non-cancerous conditions, such as ovarian cysts. On the other hand, some women have a recurrence even though their CA 125 level is normal. Neither HE4, Ovarian Cancer Monitoring nor CA125 always detect cancer.