What is the function of E-cadherin?
What is the function of E-cadherin?
E-cadherin plays an important role in the adhesion of the blastomeres, and early embryo’s ability to compact [21]. E-cadherin is expressed in the membrane even before compaction of the morula occurs, is distributed in a non-polar manner, and does not exhibit adhesive function [22,23].
Do cancer cells have high levels of E-cadherin?
1C), most of the tumor cells in the lung still expressed high levels of E-cadherin. This indicates that metastatic cells had not escaped the action of the mAb simply because they lost expression.
What percentage of gastric cancer is HER2 positive?
The phase III Trastuzumab for Gastric Cancer (ToGA) trial reported the incidence of HER2-positive gastric cancer to be 22% (8). HER2-overexpression in gastric cancer is dependent of the location of the primary tumor and ranges between 6–30% (8,9).
What is E-cadherin in cancer?
E-cadherin is a well-known tumor suppressor protein, and the loss of its expression in tumor cells, in association with the epithelial–mesenchymal transition (EMT), occurs frequently during tumor progression and metastasis (Cano et al., 2000 ; Yang and Weinberg, 2008 ; Nieto, 2011 ; Valastyan and Weinberg, 2011 ; Huang …
What is cadherin in cancer?
Abstract. In order to understand the mechanisms of metastasis, one must first determine how cancer cells detach from primary tumors. It is known that cadherins are major cell-cell adhesion molecules in tumors as well as in normal tissues.
What is HER2-positive stomach cancer?
In some people with stomach cancer, the cancer cells have too much of a growth-promoting protein called HER2 on their surface. Cancers with increased levels of HER2 are called HER2-positive. Drugs that target the HER2 protein can often be helpful in treating these cancers.
What is HER2 negative stomach cancer?
In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.
