What is the difference between VDRL and TPHA?

VDRL test is less likely to identify syphilis except in primary stage of disease where TPHA may appear non- reactive. Moreover, it produces more false-positive results at all stages and more false-negative results in late disease.

What does TPHA positive mean?

A positive test result means that antibodies against Treponema Pallidum are present indicating that the patient is having syphilis infection. However, false positive and false negative test results can also be seen in some cases.

What is VDRL positive?

A positive test result means you may have syphilis. If the test is positive, the next step is to confirm the results with an FTA-ABS test, which is a more specific syphilis test. The VDRL test’s ability to detect syphilis depends on the stage of the disease.

Is VDRL curable?

It is treatable in the early stages, but without treatment, it can lead to disability, neurological disorders, and even death. The bacterium Treponema pallidum (T. pallidum) causes syphilis. There are four stages of the disease: primary, secondary, latent, and tertiary.

Is TPHA curable?

When diagnosed and treated in its early stages, syphilis is easy to cure. The preferred treatment at all stages is penicillin, an antibiotic medication that can kill the organism that causes syphilis. If you’re allergic to penicillin, your doctor may suggest another antibiotic or recommend penicillin desensitization.

How is Vdrl transmitted?

Syphilis is most likely to spread during oral, anal, or vaginal sexual activity. People rarely pass the bacteria on through kissing. The first sign is a painless sore on either the genitals, rectum, mouth, or another part of the skin. Some people do not notice the sore, as it does not cause pain.

Is TPHA positive curable?

Which test is VDRL?

The VDRL test is a screening test for syphilis. It measures substances (proteins), called antibodies, which your body may produce if you have come in contact with the bacteria that cause syphilis. Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand.

What is the difference between VDRL and TPHA test?

VDRL stands for Venereal Disease Research Laboratory TPHA stands for Treponema Pallidum Hemagglutination Both the tests are used for syphilis. However, VDRL is a screening test and is a non-specific test while TPHA is a specific test for Treponema Pallidum. However,…

Can a VDRL test confirm the diagnosis of syphilis?

HIV and VDRL Test. In the course of reactive VDRL, the diagnosis of syphilis should be confirmed by the specific treponemal test, namely FTA-ABS or TPHA should be done along with VDRL. Reactive minimal reaction in the FTA-ABS (DS) test provides evidence for or against syphilis. Beaded reaction in the FTA-ABS…

How is the VDRL test used in real life?

Like the RPR test, the VDRL test can be quantitated by examining serial dilutions of serum and can be used to follow the course of illness, including the response to therapy. Go to: Interpretation In a healthy person, the test is negative. This means that no antibodies to the organism that causes Treponema pallidum/bacteria.

Is the VDRL test a flocculation test?

It is a qualitative test for screening of syphilis, and currently all nontreponemal tests are flocculation tests and both VDRL and RPR tests are modifications of original Wasserman reaction. Unfortunately in this test, the antibody detects antigens, which are nonspecific, thereby yielding much false-positive reaction.