What cells produce CXCL9?

CXCL9, -10, -11 are mainly secreted by monocytes, endothelial cells, fibroblasts, and cancer cells in response to IFN-γ, which are synergistically enhanced by TNF-alpha. [9, 10] CXCR3 is a receptor preferentially expressed on the surface of monocytes, T cells, NK cells, dendritic cells, and cancer cells.

What cells produce CXCL11?

CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

What produces CXCL10?

CXCL10 (interferon-γ-inducible protein 10, previously called IP-10) was initially discovered as a chemokine which is induced by interferon (IFN)-γ and is produced by a wide range of cell types including monocytes [15], neutrophils [16], endothelial cells [17], keratinocytes [18], fibroblasts [19], mesenchymal cells [20 …

What is I TAC?

Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3.

How do I lower my CXCL9?

Moreover, CXCL9 expression can be suppressed by reducing the levels of components of the STAT1‐IRF‐1(IRF‐1, Interferon regulatory factor) transcriptional activation pathway by Porphyromonas gingivalis that leads to the immune function decline 14.

Is CXCL9 a cytokine?

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG).

Is IP 10 a cytokine?

C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis.

What is the difference between chemokines and cytokines?

Cytokines are an exceptionally large and diverse group of pro- or anti-inflammatory factors that are grouped into families based upon their structural homology or that of their receptors. Chemokines are a group of secreted proteins within the cytokine family whose generic function is to induce cell migration [2, 3].

What is the role of interferon gamma?

Specifically, IFN-γ plays a major role in activating anticancer immunity, by promoting the activity of CD4 T helper type 1 cells, CD8 cytotoxic T lymphocyte (CTL), natural killer (NK) cells, dendritic cells (DCs), and macrophages, promoting the antigen presentation.