How does enoxaparin cause hyperkalemia?

[3] Heparin-induced hyperkalemia is mediated by a reversible effect on aldosterone through blockage of an enzymatic step in the synthesis and angiotensin II receptors in adrenal gland.

Is enoxaparin a factor Xa inhibitor?

Enoxaparin catalyzes the binding of antithrombin III with both factor Xa and factor IIa. Anti-factor Xa and anti-factor IIa activity results in anticoagulation.

How does enoxaparin help pregnancy?

Enoxaparin has been increasingly used over the past 20 years in pregnant women at risk of thrombosis and pregnancy complications. The main indications are prophylaxis of venous thromboembolism and prevention of pregnancy loss in thrombophilic women.

Does enoxaparin affect potassium?

Enoxaparin was the probable cause for profound hyperkalemia in our patient. Further investigations are needed to determine the underlying mechanisms involved and predisposing patient factors. Clinicians should consider regular monitor of serum potassium in patients receiving thromboprophylactic enoxaparin.

Which is used as antidote for heparin?

Expert opinion: Despite of the low therapeutic index, protamine is the only registered antidote of heparins. The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and blood cells.

Does enoxaparin increase INR?

We demonstrate an increase in the INR for patients who received enoxaparin for post-operative VTE prophylaxis.

When do you not give enoxaparin?

You should not use enoxaparin if you are allergic to enoxaparin, heparin, benzyl alcohol, or pork products, or if you have: active or uncontrolled bleeding; or. if you had decreased platelets in your blood after testing positive for a certain antibody while using enoxaparin within the past 100 days.

Is Lonopin and enoxaparin same?

LONOPIN contains Enoxaparin which belongs to a group of medicine called low molecular weight heparin or LMWH. It is used to prevent and treat blood clots. It works by stopping the existing blood clots from getting bigger.

How is enoxaparin calculated?

All treatment doses of enoxaparin are based on actual body weight. The patient must be weighed. Ensure the weight is clearly documented on the front of the Inpatient Medical Chart and in the medical notes. 1.1 Calculate the dose according to indication and renal function using actual body weight (table 1).