What is guanidine hydrochloride used for?

Guanidine hydrochloride is also available as an orally administered human drug. Its use is for the treatment of muscle weakness and easy fatigue caused by a rare disease known as the myasthenic syndrome of Eaton-Lambert, which is associated with small-cell carcinoma of the lung.

What is the difference between guanidine and guanidinium?

As nouns the difference between guanidine and guanidinium is that guanidine is (organic compound) a strong base hn=c(nh2)2 obtained by the oxidation of guanine while guanidinium is (organic chemistry) the cation derived from guanidine.

What is guanidine toxicity?

Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.

Is guanidine hydrochloride acidic?

Guanidinium chloride or guanidine hydrochloride, usually abbreviated GdmCl and sometimes GdnHCl or GuHCl, is the hydrochloride salt of guanidine….Guanidinium chloride.

Names
Melting point	182.3 °C (360.1 °F; 455.4 K)
Solubility in water	2.15 g/ml at 20 °C
Acidity (pKa)	13.6
Hazards

How do you store guanidine hydrochloride?

Guanidine·HCl solutions are stable at room temperature for several days (for longer periods, store at 4°C).

Why guanidine is a strong base?

It is a highly stable +1 cation in aqueous solution due to the efficient resonance stabilization of the charge and efficient solvation by water molecules. As a result, its pKaH is 13.6 meaning that guanidine is a very strong base in water; in neutral water, it exists almost exclusively as guanidinium.

How does guanidine hydrochloride work?

Guanidine hydrochloride (GuHCl) is a small hydroscopic molecule. It plays a role in inhibiting heat shock protein 104 (Hsp104) adenosine triphosphatase (ATPase) activity in vivo. It is a potent denaturant and inactivator of several enzymes and proteins. GuHCl can inactivate aminoacylase and papain.

Is guanidine an amino acid?

Besides being the most alkaline amino acid, the arginine molecule contains a positively charged guanidine group, similar to guanidine hydrochloride, and has been used in many refolding systems to suppress protein aggregation.

How do you dissolve guanidine hydrochloride?

In order to make an 8 M solution in water, one must heat the solution to 35 °C for approximately 30 minutes. The maximum solubility of guanidine hydrochloride in water at room temperature is approximately 6 M.

How do you remove guanidine hydrochloride?

The refolding of proteins from the insoluble cellular fraction is commonly accomplished by solubilizing the protein in a chaotropic agent, such as guanidine hydrochloride (GuHCl) or urea, and then removing the denaturant by dialysis or rapid dilution.

Is guanidine hydrochloride hazardous?

Harmful if swallowed, inhaled, or absorbed through skin. Causes skin, eye and respiratory tract irritation. Hygroscopic. Protect from moisture.

Which is the strongest base guanidine?

What are the medical uses of guanidine hydrochloride?

Medical uses. Guanidine hydrochloride is indicated for the reduction of the symptoms of muscle weakness and easy fatigability associated with Eaton-Lambert syndrome. It is not indicated for treating myasthenia gravis. It apparently acts by enhancing the release of acetylcholine following a nerve impulse.

What can be done with a concentration of 8m guanidine?

• Any concentration below 8M guanidine can be quickly and easily prepared. Applications of Guanidine Hydrochloride: Chaotropes, substances that disrupt the structure of water interactions, help to solubilize hydrophobic proteins and peptides for a variety of biological purposes.

What is the standard state of guanidine chloride?

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ?) Guanidinium chloride or guanidine hydrochloride, usually abbreviated GuHCl and sometimes GdnHCl or GdmCl, is the hydrochloride salt of guanidine .

What can Thermo Scientific Pierce guanidine HCl do?

Thermo Scientific Pierce Guanidine-HCl can be easily dissolved and pH-adjusted to any concentration. Chaotropes, substances that disrupt the structure of water interactions, help to solubilize hydrophobic proteins and peptides for a variety of biological purposes.