What is the mechanism action of aspirin?

The acetyl group of acetylsalicylic acid binds with a serine residue of the cyclooxygenase-1 (COX-1) enzyme, leading to irreversible inhibition. This prevents the production of pain-causing prostaglandins.

What is the action of aspirin as an antiplatelet?

The antithrombotic action of aspirin (acetylsalicylic acid) is due to inhibition of platelet function by acetylation of the platelet cyclooxygenase (COX) at the functionally important amino acid serine529.

What is the expected pharmacological action of aspirin?

Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body to reduce pain and swelling.

What is the pharmacological classification of aspirin?

Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain1,2 or inflammation. It is classified as a non-steroidal anti-inflammatory drug (NSAID).

What are the mechanism of action and adverse effect of aspirin?

He proved that aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever.

Does aspirin reduce platelet?

“Aspirin has been proven by all previous studies to lower the risk of stroke and, as our latest findings show, it also reduces platelet aggregation that can lead to potentially fatal clots in blood vessels.”

What is the action of aspirin so important?

Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins and TXA2.

What is the mechanism of action of atropine?

Mechanism of Action. Atropine is an antimuscarinic that works through competitive inhibition of postganglionic acetylcholine receptors and direct vagolytic action, which leads to parasympathetic inhibition of the acetylcholine receptors in smooth muscle.

What are the side effects of atropine sulfate?

Atropine or atropine sulfate carries FDA indications for anti-sialagogue/anti-vagal effect, organophosphate/muscarinic poisoning, and bradycardia. Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug.

What is the anti inflammatory action of aspirin?

Aspirin is a weak organic acid which irreversibly inactivates cyclooxygenase by acetylating it (by transferring its acetyl group). The inactivation of cyclooxygenase inhibits production of prostaglandins from arachidonic acid. This results in analgesic, anti-pyretic and anti-inflammatory action of aspirin.

When to take atropine intravenously or by intravenous?

If there are local symptoms to the eyes or respiratory tract, atropine is not indicated. Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, or bradycardia. Large doses and repeat doses may be required. Ingestions especially require higher doses (up to 20 mg).