What eplerenone is used for?

About eplerenone It’s used to treat heart failure and reduce the risk of you having other heart problems or a stroke. It also helps to stop heart failure getting worse. It can sometimes be used to treat a condition called hyperaldosteronism.

Why is eplerenone used in heart failure?

In the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS),3 the selective mineralocorticoid-receptor antagonist eplerenone, added to recommended medical therapy, reduced the rates of death from any cause and hospitalization for cardiovascular reasons among patients with …

When is it appropriate to initiate eplerenone?

However, once the patient is stable, has evidence of HFREF, and no contraindications to the use of an MRA (such as a serum potassium >5.0 meq/l and/or an eGFR <30 ml/min/1.73 m2), it should be initiated.

Does eplerenone improve ejection fraction?

Eplerenone might be effective in reducing the incidence of these adverse clinical outcomes during this period. The EMPHASIS-HF trial compared eplerenone with placebo added to standard therapy in 2737 patients with New York Heart Association class II HF and left ventricular ejection fraction ≤35%.

Is eplerenone bad for kidneys?

If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

Who should not take eplerenone?

do not take eplerenone if you are taking amiloride (Midamor), amiloride and hydrochlorothiazide, itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), potassium supplements, spironolactone (Aldactone), spironolactone and hydrochlorothiazide (Aldactazide), triamterene (Dyrenium), or triamterene and hydrochlorothiazide …

Does eplerenone affect heart rate?

Eplerenone reduced the risk of primary endpoint, the composite of cardiovascular death and hospitalisation for heart failure, by 30% (aHR 0.70; 95% CI 0.54-0.91) in subjects with heart rate ≥ 80 bpm, and by 48% (aHR 0.52; 95% CI 0.33-0.81) in subjects with heart rate ≤ 60 bpm.

What are the side effects of eplerenone?

Eplerenone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache.
• dizziness.
• diarrhea.
• stomach pain.
• cough.
• excessive tiredness.
• flu-like symptoms.
• breast enlargement or tenderness.

Does eplerenone cause weight gain?

Significant treatment effect in favor of eplerenone was observed in 5 symptoms: ankle swelling, weight gain, nocturia, increased urination, and shortness of breath. Patients with symptom distress also showed an erosion of psychosocial measures of quality of life (P<. 001).

Is eplerenone a good diuretic?

General information. Eplerenone is a potassium-sparing diuretic. It is similar to spironolactone as an aldosterone antagonist, but has less affinity for androgen and progesterone receptors and may therefore have fewer adverse effects [1].

Does eplerenone cause erectile dysfunction?

The most common reported adverse events in patients receiving eplerenone was headache (11.6%); however, the frequency was not significantly higher than in those receiving placebo. One patient each in the eplerenone 100 mg and placebo group experienced impotence (6).

Does eplerenone cause hair loss?

Eplerenone has a higher affinity for the aldosterone receptor than spironolactone and is claimed to have fewer anti-androgenic effects (gynecomastia, hair loss).

Is it safe to take eplerenone in high risk patients?

Conclusions: In patients with chronic HF-REF, in NYHA functional class II, and meeting specific inclusion and exclusion criteria, including an eGFR >30 ml/min/1.73 m (2) and potassium <5.0 mmol/l, eplerenone was both efficacious and safe when carefully monitored, even in subgroups at high risk of developing hyperkalemia or WRF.

How often should I take eplerenone or spironolactone?

Spironolactone Eplerenone Initial Dose 12.5 mg to 25 mg once daily. (12.5 mg daily or every other day. if eGFR < 50 to 30 mL/min/1.73 m2)1 25 mg once daily. (25 mg every other day.

How are Patients randomly assigned to receive eplerenone?

We used a computerized randomization system involving concealed study-group assignments to randomly assign patients to receive eplerenone (Inspra, Pfizer) or matching placebo.

How is eplerenone used to treat systolic heart failure?

The aim of our Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF) was to investigate the effects of eplerenone, added to evidence-based therapy, on clinical outcomes in patients with systolic heart failure and mild symptoms (i.e., NYHA functional class II symptoms). 6