What is Tasmar used for?

TASMAR is indicated as an adjunct to levodopa and carbidopa for the treatment of the signs and symptoms of idiopathic Parkinson’s disease.

What kind of drug is tasmar?

This medication is used with other medications (levodopa/carbidopa) to treat Parkinson’s disease. Tolcapone belongs to a class of drugs known as COMT inhibitors.

Why was the COMT drug tolcapone Tasmar withdrawn from the market?

It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which has led to suspension of marketing authorisations in a number of countries.

Does tolcapone cause liver failure?

Liver injury caused by tolcapone ranges from mild, transient and asymptomatic serum enzyme elevations to clinically apparent hepatitis and acute liver failure.

Is selegiline an antidepressant?

Transdermal selegiline, an irreversible selective monoamine oxidase B (MAO-B) inhibitor, is approved as an antidepressant in the USA. Some reports have shown that oral selegiline treatment can also be effective in treating depression.

What are the side effects of entacapone?

Entacapone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• dizziness.
• diarrhea.
• upset stomach.
• movements you cannot control.
• stomach pain.
• drowsiness.

What does COMT mean?

Catechol-O-methyl-transferase (COMT) is an enzyme responsible for the degradation of catecholamines, such as dopamine and norepinephrine.

Why are carbidopa and levodopa usually given together?

Adding carbidopa prevents levodopa from being converted into dopamine in the bloodstream. This allows more of the drug to get to the brain. This also means that lower doses of levodopa can be given. The addition of carbidopa also reduces the risk of some side effects like nausea or vomiting.

Is there another name for entacapone?

Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson’s disease.