How does PCP affect the central nervous system?

Phenycyclidine (PCP) produces many profound effects in the central nervous system. PCP has numerous behavioral and neurochemical effects such as inhibiting the uptake and facilitating the release of dopamine, serotonin, and norepinephrine. PCP also interacts with sigma, mu opioid, muscarinic, and nicotinic receptors.

How does PCP affect the synapse?

PCP reduced the number of synaptic sites, expression of synaptic proteins, and release of glutamate.

What receptors does PCP effect?

PCP is well known for its primary action on the NMDA receptor, an ionotropic glutamate receptor, in rats and in rat brain homogenate. As such, PCP is an NMDA receptor antagonist.

What neurotransmitter does PCP effect?

PCP also alters the actions of dopamine, a neurotransmitter responsible for the euphoria and “rush” associated with many abused drugs. Salvia divinorum works differently.

What happens when you block the reuptake?

The reuptake process is susceptible to drug manipulation. By blocking the action of serotonin reuptake inhibitors (SERTs), the amount of serotonin in the synaptic cleft increases.

What is the best SNRI for depression?

The Food and Drug Administration (FDA) has approved these SNRIs to treat depression:

• Desvenlafaxine (Pristiq)
• Duloxetine (Cymbalta) — also approved to treat anxiety and certain types of chronic pain.
• Levomilnacipran (Fetzima)
• Venlafaxine (Effexor XR) — also approved to treat certain anxiety disorders and panic disorder.

What is the best SNRI for anxiety?

These are the most commonly prescribed SNRI medications for anxiety:

• Effexor (venlafaxine)
• Pristiq (desvenlafaxine)
• Cymbalta (duloxetine)

What are some of the side effects of PCP?

PCP is classified as a hallucinogen. PCP is a “dissociative” drug; it induces distortion of sight and sound and produces feelings of detachment. PCP’s effects include sedation, immobility, amnesia, and marked analgesia. The effects of PCP vary by the route of administration and dose.

Which is the most common route of PCP use?

PCP is available in a variety of tablets, capsules, and colored powders, which are either smoked, taken orally or by the intranasal route (“snorted”). Smoking is the most common route when used recreationally.

How does route of administration affect the effect of a substance?

The route with which a substance has been administered can greatly impact its potency, duration, and subjective effects. For example, many substances are more effective when consumed using particular routes of administration, while some substances are completely inactive with certain routes.

Which is the most common route of drug abuse?

Some routes of administration for drug abuse are pretty common, such as smoking, snorting, and oral routes. There are also other less popular methods of abuse, such as rectal administration, that can be just as dangerous, if not more so. Not all drugs can be taken the same way, and taking some drugs in different ways can lead to unwanted outcomes.