What is LHRH agonist therapy?

Luteinizing hormone-releasing hormone (LHRH) agonists (also called LHRH analogs or GnRH agonists) are drugs that lower the amount of testosterone made by the testicles. Treatment with these drugs is sometimes called medical castration because they lower androgen levels just as well as orchiectomy.

How do LHRH agonists lower testosterone?

LHRH agonists are decapeptides that exert a nonpulsatile, constant stimulation to the anterior pituitary gland, which in turn decreases LH and testosterone production.

What is the difference between LHRH agonist and LHRH antagonist?

LHRH antagonists bind to the LHRH receptors on pituitary gonadotropin-producing cells. They do not cause an initial release of luteinizing hormone or follicle-stimulating hormone, and thus avoiding the flare phenomenon of LHRH agonists.

How do GnRH agonists work in prostate cancer?

GnRH agonists bind to the GnRH receptors on pituitary gonadotropin-producing cells, causing an initial release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and consequently a rise in testosterone levels for a few weeks.

What is the anti testosterone hormone?

Antiandrogens are the name given to a diverse group of medicines that counteract the effects of the male sex hormones, testosterone and dihydrotestosterone. Male sex hormones are also known as androgens; antiandrogens may also be called androgen receptor blockers.

How do you stop testosterone?

Here are 8 foods that lower testosterone levels you may want to watch out for.

1. Soy and Soy-Based Products. Some research shows that regularly eating soy products like edamame, tofu, soy milk and miso may cause a drop in testosterone levels.
2. Mint.
3. Licorice Root.
4. Vegetable Oil.
5. Flaxseed.
6. Processed Foods.
7. Alcohol.
8. Nuts.

What are the LHRH agonists?

A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, LHRH agonists cause the testicles to stop making testosterone. In women, they cause the ovaries to stop making estrogen and progesterone.

What is LHRH used for?

LHRH agonists are used in the following ways in the management of metastatic prostate cancer: On their own for the long-term, continuous suppression of the male hormone testosterone. In combination with other drugs (such as nonsteroidal antiandrogens) for continous suppression of testosterone and other male hormones.

Does hormone therapy weaken immune system?

Does hormone therapy affect the immune system? Taking hormone therapy does not affect your immune system. Hormone therapies, including tamoxifen, letrozole, anastrozole, exemestane and goserelin, do not affect your risk of getting coronavirus or of becoming seriously ill if you do get it.

What are LHRH agonists and how do they work?

What are LHRH Agonists, and How Do They Work? LHRH agonists are synthetic analogs of the normal human hormone luteinizing hormone-releasing hormone, which is produced in the human hypothalamus and stimulates the production of a second hormone known as luteinizing hormone (LH).

When to start LHRH agonist therapy for prostate cancer?

For various reasons discussed elsewhere on this web site, many men today start to receive LHRH agonist therapy long before they have any specific evidence of metatstatic prostate cancer, and it is not uncommon to come across men who have received hormone therapy either continuously or intermittently for 10 years or more.

Which is the best GnRH agonist for women?

Common GnRH agonists are: Brand name, Zoladex. A medicine that belongs to a family called gonadotropin-releasing hormone analogs. Goserelin is used to block hormone production in the ovaries or testicles. It is used in the treatment of advanced breast cancer. Having to do with the time before menopause.

When was the luteinizing hormone ( LHRH ) released?

The first luteinizing hormone-releasing hormone (LHRH) agonists were synthesized in the 1970s and leuprolide acetate became available for the treatment of prostate cancer in the 1980s. Today there are several LHRH agonists commonly used in treatment of prostate cancer.