Can NSIP progress UIP?

A honeycombing appearance equal to or greater than 8% was identified in none with NSIP; however, there were many instances of UIP with a honeycombing appearance of less than 8%. The sensitivity of many CT findings for distinguishing UIP from NSIP was very low.

Is UIP same as IPF?

The term UIP is often used interchangeably with idiopathic pulmonary fibrosis (IPF), but other clinical conditions are associated with UIP, although less commonly, including collagen vascular disease, drug toxicity, chronic hypersensitivity pneumonitis, asbestosis, familial IPF, and Hermansky-Pudlak syndrome.

What is a UIP?

Abstract. Usual interstitial pneumonia (UIP) is a distinct histological lesion observed in idiopathic pulmonary fibrosis (IPF) but can be found in other etiologies.

Does NSIP go away?

Both inflammation and fibrosis may be present at the same time. Generally, the prognosis is better for patients with the cellular form of NSIP as inflammation is often reversible but fibrosis is permanent.

Is UIP serious?

Prognosis. Regardless of cause, UIP is relentlessly progressive, usually leading to respiratory failure and death without a lung transplant. Some patients do well for a prolonged period of time, but then deteriorate rapidly because of a superimposed acute illness (so-called “accelerated UIP”).

Is UIP curable?

The only available treatments to show benefit in proper studies is a combination of low-dose prednisolone with azothioprine and N-acetylcysteine (triple therapy), which was shown to be better than prednisolone and azothioprine alone; whether either treatment is better than nothing awaits further study.

Is NSIP serious?

Outlook / Prognosis The prognosis for patients with cellular NSIP is excellent, with a low mortality rate. In the case of fibrotic NSIP, the prognosis is less favorable, with a median survival period of six to 13.5 years after diagnosis.

Is NSIP an ILD?

When idiopathic, NSIP is considered one of the idiopathic interstitial pneumonias (IIPs), which also include usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF), desquamative interstitial pneumonia (DIP), respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), acute interstitial …

Which is the key differential between NSIP and UIP?

The key differential is the usual interstitial pneumonitis (UIP) pattern, with which there can be some overlap in imaging features 3. The features which favor the diagnosis of NSIP over UIP are symmetrical bilateral ground-glass opacities with fine reticulations and sparing of the immediate subpleural space.

What’s the difference between NSIP and usual interstitial pneumonia?

Interstitial pneumonia that cannot be categorized is referred to as NSIP, which includes three subtypes. However, there are questions regarding the possible similarities between NSIP and usual interstitial pneumonia (UIP).

How many people are diagnosed with NSIP and UIP?

The study included 54 patients with NSIP and 42 patients with UIP (55 men, 41 women; mean age, 60.2 years ± 9.2 [standard deviation]; age range, 33–77 years). Two independent readers assessed the CT images and made a first-choice diagnosis. The appearances of UIP and NSIP at CT were compared with univariate and multivariate analyses.

Which is a predictor of the presence of NSIP?

Misumi and Lynch (, 4) described that the presence of subpleural sparing strongly favors NSIP. Bna and coworkers (, 5) suggested that the presence of ground-glass abnormalities involving more than 15% of the lung was a significant predictor of the presence of NSIP rather than UIP.