What does a speckled pattern ANA mean?

Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren’s syndrome, Systemic Sclerosis, Polymyositis, and Rheumatoid Arthritis.

What is nuclear ANA pattern?

The pattern of the ANA test can give information about the type of autoimmune disease present and the appropriate treatment program. A homogenous (diffuse) pattern appears as total nuclear fluorescence and is common in people with systemic lupus.

What are the ANA patterns?

ANAs present different “patterns” depending on the staining of the cell nucleus in the laboratory: homogeneous or diffuse pattern; speckled pattern; nucleolar pattern; and peripheral or rim pattern.

What is an ANA pattern test?

What is an ANA (antinuclear antibody) test? An ANA test looks for antinuclear antibodies in your blood. If the test finds antinuclear antibodies in your blood, it may mean you have an autoimmune disorder. An autoimmune disorder causes your immune system to attack your own cells, tissues, and/or organs by mistake.

Is a positive ANA test serious?

The presence of antinuclear antibodies is a positive test result. But having a positive result doesn’t mean you have a disease. Many people with no disease have positive ANA tests — particularly women older than 65.

Does speckled ANA mean lupus?

Peripheral or rim (only the outline of the nucleus is seen, like a halo)—not common, almost always indicates lupus. Speckled (tiny dots throughout the nucleus)—a common pattern, not specific, but often indicating anti-Sm or anti-RNP antibodies (see below) found in lupus or mixed connective tissue disease.

What ANA pattern is most common?

The most frequent ANA patterns were coarse speckled pattern (154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern (57 patients, 11.5%), and speckled pattern (48 patients, 9.7%).

Can leukemia cause a positive ANA?

Background: Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), but the prognostic value of ANAs remains unknown.

Can flu cause positive ANA?

Blood samples were taken from each participant before annual influenza vaccination, one month and six months after vaccination. Before influenza vaccination 26% of participants were positive for ANA, 1% for anti-ENA, 16% for aCL, 7% for aβ2-GPI and 2% for LA.

What is Ana pattern test?

The ANA test is reported as a titer and a pattern. The titer represents the number of times the blood needs to be diluted to eliminate the autoantibody from serum. A higher titer, therefore, represents a higher level of autoantibody in the serum although this is not a reliable measurement of disease activity.

What is Ana nuclear pattern?

Nuclear Membrane. This is an example of an unusual ANA pattern called nuclear membrane. This pattern is characterized by smooth staining in the nucleus of the interphase cells (a). The nucleoli may or may not stain.

What is a mixed Ana pattern?

Mixed ANA Patterns: Overview. The presence of more than one ANA pattern in a sample is referred to as a mixed ANA pattern. The most common of these is a mixture of Homogeneous and Speckled, but any combination is possible.

What does Ana nuclear pattern speckled mean?

Speckled ANA pattern called Nuclear Matrix. This pattern is characterized by coarse granular speckled staining in the nucleus of the interphase cells. The nucleoli do not stain and the speckles tend to outline the nucleoli.