What is the gene code for TNF alpha?
What is the gene code for TNF alpha?
Tumor necrosis factor (TNF, cachexin, or cachectin; often called tumor necrosis factor alpha or TNF-α) is a cytokine – a small protein used by the immune system for cell signaling….Tumor necrosis factor.
| TNF | ||
|---|---|---|
| UniProt | P01375 | P06804 |
| RefSeq (mRNA) | NM_000594 | NM_001278601 NM_013693 |
| RefSeq (protein) | NP_000585 | NP_001265530 NP_038721 |
What is the receptor for TNF alpha?
TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK.
What is the TNF gene?
The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF gene is an immediate early gene, rapidly transcribed in a variety of cell types following exposure to a broad range of pathogens and signals of inflammation and stress.
What does TNF code for?
TNF (Tumor Necrosis Factor) is a Protein Coding gene. Diseases associated with TNF include Asthma and Malaria.
Why is tumor necrosis bad?
Tumor necrosis is often associated with aggressive tumor development and metastasis and is thought to be an indication of poor prognosis of patients with breast, lung and kidney cancer [38, 39].
What are the GeneCards for the TNF gene?
GeneCards Summary for TNF Gene. TNF (Tumor Necrosis Factor) is a Protein Coding gene. Diseases associated with TNF include Malaria and Asthma. Among its related pathways are Apoptosis Modulation and Signaling and Interleukin-10 signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and cytokine activity.
What is the role of TNF alpha in inflammation?
Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and …
What kind of protein is induced by TNF?
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis.
Which is a trimer of the TNF alpha receptor?
TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK.
