What is CD47 used for?

CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells. The body uses the CD47 protein to protect cells that should be protected and to help dispose of cells that are aged or diseased.

What are anti-CD47 drugs?

Anti-CD47 antibodies enhance the phagocytosis of tumor cells by macrophages by directly blocking the binding of tumor cell-expressing CD47 to macrophage-expressing SIRPα (18).

How do I block CD47?

To block erythrocyte CD47, anti-CD47 B6H12 monoclonal antibody was used. The B6H12 antibody blocks the interaction between CD47 and SIRP-α. IgG was used as a control. The dose of 10 or 20 µg/mL has been found to enhance phagocytosis of tumor cells.

Do macrophages express CD47?

While calreticulin can be induced on cancer cells, macrophages can also secrete calreticulin that binds to cancer cells leading to macrophage phagocytosis (20). As a protective mechanism to this pro-phagocytic stimulus, cancer cells upregulate CD47 to evade phagocytosis.

Is CD47 a gene?

GeneCards Summary for CD47 Gene CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall.

What TTI 621?

Purpose: TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates antitumor activity by blocking the CD47 “don’t eat me” signal. This first-in-human phase I study (NCT02663518) evaluated the safety and activity of TTI-621 in relapsed/refractory (R/R) hematologic malignancies.

What does PD 1 do?

A protein found on T cells (a type of immune cell) that helps keep the body’s immune responses in check. When PD-1 is bound to another protein called PD-L1, it helps keep T cells from killing other cells, including cancer cells.

Is CD47 an innate immune checkpoint for tumor evasion?

Thus, CD47 is a checkpoint molecule for both innate and adaptive immunity for tumor evasion.

What is Magrolimab?

A humanized monoclonal antibody targeting the human cell surface antigen CD47, with potential immunostimulating and antineoplastic activities.

Who discovered CD47?

Concurrently, Eric Brown had discovered CD47 2 and suggested that it might be the TSP1 receptor. We confirmed that the 50 kDa protein was recognized by several CD47 antibodies and that the TSP1 G domain peptides augmented integrin functions such as chemotaxis and cell spreading in a CD47-dependent manner 5, 26.