What is the normal range for C-peptide?

A normal result is between 0.5 to 2.0 nanograms per milliliter (ng/mL), or 0.17 to 0.83 nanomoles per liter (nmol/L). Normal value ranges may vary slightly among different laboratories.

How do you interpret C-peptide levels?

Normal results are within the range of 0.5 to 2.7 ng/mL, but can vary depending upon the lab that is used for testing. A high level of C-peptide could mean a number of conditions. These include a kidney problem or an insulinoma, a tumor of the insulin-making cells in the pancreas.

What is the C-peptide range in type 1 diabetes?

Specifically a c-peptide level of less than 0.2 nmol/l is associated with a diagnosis of type 1 diabetes mellitus (T1DM).

How do C-peptide levels increase in Type 1 Diabetes?

Nicotinamide (niacin) can help increase pancreatic beta-cell function. Niacin supplementation over a year increased C-peptide levels in 36 patients with recent onset type 1 diabetes [11].

What is the C-peptide range in type 2 diabetes?

You should have your results in a few days. A normal C-peptide range is 0.5 to 2.0 nanograms per milliliter. These levels can be high when your body makes more insulin than usual. Levels are low when your body makes less than it normally should.

Can Type 2 have low C-peptide?

If your C-peptide level is lower than normal, it means that your body doesn’t produce enough insulin. Causes of a low C-peptide level include: both type 1 and type 2 diabetes (people with type 1 diabetes typically have even lower C-peptide levels than people with type 2 diabetes) a poorly functioning pancreas.

What if my C-peptide is high?

A high level of C-peptide can mean your body is making too much insulin. It may be a sign of one of the following conditions: Type 2 diabetes. Insulin resistance, a condition in which the body doesn’t respond the right way to insulin.

Does a low C-peptide indicate type 1 diabetes?

A low level of C-peptide can mean your body isn’t making enough insulin. It may be a sign of one of the following conditions: Type 1 diabetes. Addison disease, a disorder of the adrenal glands.

What is considered a low C-peptide?

What is normal blood insulin level?

Using commercial assays, normal fasting insulin levels range between 5 and 15 µU/mL but with more sensitive assays normal fasting insulin should be lower than 12 µU/mL. Obese subjects have increased values, while very high circulating levels are found in patients with severe insulin resistance.

What is considered a low C-peptide level?

If levels of C-peptide are abnormally low in a blood test (under 0.5 ng/mL), the levels of endogenous insulin production are also low. It is therefore likely that the patient is at higher risk for insulin dependence, or may have undiagnosed T1DM. Low C-peptide results may also be indicative of an insulin overdose.

What causes low C-peptide?

Causes of a low C-peptide level include: both type 1 and type 2 diabetes (people with type 1 diabetes typically have even lower C-peptide levels than people with type 2 diabetes) a poorly functioning pancreas. fasting for a long period, which affects your insulin levels.

What’s the normal range for a C-peptide test?

Normal Range The normal range for fasting blood C-peptide levels is around 0.8 – 3.85 ng / mL or 0.26 – 1.27 nmol / L (260 – 1270 pmol / L). Ranges can vary between laboratories. Levels below 0.6 ng/mL (0.2 nmol/L) are a sign of possible beta cell failure and type 1 diabetes [ 2, 1 ].

What should the C peptide level be during insulinoma?

A C-peptide concentration greater than 300 pmol/L during a hypoglycaemic episode (concurrant glucose <2.5 mmol/L), is inappropriately high suggesting insulinoma or sulfonylurea ingestion. C-peptide is considered appropriately supressed if less than 94 pmol/L during hypoglycaemia. Indeterminate values are 94-300 pmol/L.

Why are C peptide levels high in type 2 DM?

C-peptide and insulin are two faces from the same coin, they come high or low at the same time. If the diagnosis is type 2 DM at the beginning then your c-peptide and insulin should become higher over the time to overstimulate cells to absorb more sugar.

Why are C-peptide levels higher in urine?

The concentration in urine is about 20‑50 fold higher than in serum. C‑peptide concentrations are therefore elevated in renal disease. In the past, C‑Peptide has been considered biologically inactive.