Is PAX3 a transcription factor?
Is PAX3 a transcription factor?
The PAX3 protein is a transcription factor consisting of an N-terminal DNA binding domain (containing a paired box and homeodomain) and a C-terminal transcriptional activation domain.
What is TCF3?
Recent studies have shown that T-Cell Factor-3 (Tcf3), a terminal component of the Wnt pathway, acts to repress the Nanog gene in ES cells (Pereira et al. 2006), providing an important clue for at least one mechanism by which the Wnt pathway regulates stem cell state.
What is an architectural transcription factor?
Architectural proteins influence structural aspects of enhanceosomes through protein:DNA as well as protein:protein interactions. These families of proteins interact with specific structural features of DNA, modulate transcription factor binding to DNA, and interact directly with other transcription factors.
Where is the PAX3 gene located?
The human PAX3 gene is located in the 2q36. 1 chromosomal region, and contains 10 exons within a 100 kb region.
What protein does PAX3 produce?
The transcriptional product of the PAX3–FKHR chimeric gene is a 7.2-kb transcript in which the 5′ PAX3 and 3′ FKHR coding sequences are fused in-frame to generate a 2508 nucleotide open reading frame encoding an 836 amino acid fusion protein.
Is STAT3 a transcription factor?
STAT3 belongs to the signal transducer and activator of transcription (STAT) family of signal responsive transcription factors which consists of seven members encoded by distinct genes. In non-stimulated cells, STAT3, like other STATs proteins, is kept in an inactive cytoplasmic form.
What does the TCF4 gene do?
The TCF4 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and helps control the activity of many other genes. On the basis of this action, the TCF4 protein is known as a transcription factor. The TCF4 protein is part of a group of proteins known as E-proteins.
