What is exfoliative toxin responsible for?
What is exfoliative toxin responsible for?
The exfoliative toxins of Staphylococcus aureus are responsible for the staphylococcal scalded skin syndrome, a blistering skin disorder that particularly affects infants and young children, as well as adults with underlying disease.
What is the mechanism of action for exfoliative toxin?
It is speculated that binding of the N-terminal alpha-helix to desmoglein-1 results in a conformation change that opens the active site of the toxin to cleave the extracellular domain of desmoglein-1 between the third and fourth domains, resulting in disruption of intercellular adhesion and formation of superficial …
What effect does exfoliative toxins have on the human organism?
Exfoliative toxins cause blistering skin diseases known as bullous impetigo and staphylococcal scalded-skin syndrome (SSSS). Three isoforms of exfoliative toxins (ETA, ETB, and ETD) have been identified in virulent strains of S. aureus and four isoforms have been shown to exist in the animal pathogen S.
What is exfoliative toxin in biology?
The exfoliative toxins (ETs) also known as epidermolytic toxins, are serine proteases secreted by S. aureus that recognize and hydrolyze desmosome proteins in the skin. ETs have been described as exotoxins produced by certain S.
Is exfoliative toxin A superantigen?
Viewing the data as a whole, we conclude that SSSS is not a superantigen-mediated disease and that the exfoliative toxins are not superantigens. The data and the clinical picture of SSSS support our thesis that these toxins are most likely unique serine proteases which act on an unknown target in the upper epidermis.
Which toxin is responsible for staphylococcal scalded skin syndrome?
The exfoliative (epidermolytic) toxins of Staphylococcus aureus are the causative agents of the staphylococcal scalded-skin syndrome (SSSS), a blistering skin disorder that predominantly affects children.
What staphylococcal toxin is responsible for the peeling skin seen in scalded skin syndrome?
Exfoliative toxin (EF) This kind of toxin is mostly observed in the case of infants and young children having Staphylococcal infection. The nurseries associated with hospitals may also posses EF. The released exfoliative toxins and their protease activity cause peeling off effect on skin surface [13].
What type of exotoxin is exfoliative toxin?
