Why does fluorocitrate inhibit aconitase?
Why does fluorocitrate inhibit aconitase? Fluorocitrate is converted to fluoro-cis-aconitate and then to 4-hydroxy-trans-aconitate (HTn) which binds tightly to aconitase and inhibits its action. It does this by displacing the double bond closest to the Fe and preventing the hydration of the double bond. What does fluoroacetate do to cellular Read more…