How does PBP2a work?

How does PBP2a work? PBP2a is a unique transpeptidase that is not inhibited well by β-lactam antibiotics. Hence, it is able to continue peptidoglycan crosslinking in the face of the challenge by these antibiotics, when other PBPs with transpeptidase activity are inhibited. Crosslinking of peptidoglycan strands in cell-wall synthesis. Does Read more…

Do trills always go up?

Do trills always go up? Trills provide the flutes and other woodwinds the opportunity to add brilliance and excitement to a score. Forgive me for stating the obvious, but a trill is a rapid alternation between adjacent pitches, up either a half step or whole step from the notated pitch Read more…