How COX inhibitors cause asthma?

How COX inhibitors cause asthma? Inhibition of COX enhances bronchoconstriction in mice (2). Furthermore, in a subgroup of patients with asthma, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) induce bronchoconstriction and acute asthma, resulting in the “aspirin-sensitive asthma” condition (3). What is the mechanism of action of COX inhibitors? COX-2 Read more…