What is low risk myelofibrosis?

What is low risk myelofibrosis? Low-Risk Myelofibrosis (MF) Patients Patients who are symptom-free (called “asymptomatic”) and do not have signs of anemia, an enlarged spleen or other complications, are generally not treated. Some people remain stable and symptom-free for many years. What is the most common presenting symptom of myelofibrosis? Read more…

Does Bcl-2 trigger apoptosis?

Does Bcl-2 trigger apoptosis? The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis. Does Bcl-2 promote cell proliferation? Bcl-2 decreases cell proliferation and promotes accumulation Read more…