Does Bcl-2 trigger apoptosis?

Does Bcl-2 trigger apoptosis? The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis. Does Bcl-2 promote cell proliferation? Bcl-2 decreases cell proliferation and promotes accumulation Read more…