How do you dilute imipenem?

Each 500mg of dose should be diluted with 100ml of compatible IV fluid, whilst for a 1gm dose use a 250ml bag. Infuse doses of 500mg over 20 minutes. Infuse doses of 500mg to 1gm over 40 to 60 minutes. If patient develops nausea during infusion, the rate of infusion may be slowed.

What is Tienam used for?

Tienam is an antibiotic used in complicated infections, generally in hospital. It has been used to treat infections of the lungs, the urinary tract (structures that carry urine), the abdomen, skin and the reproductive system. It can also be used in patients whose immune system is weakened when they have a fever.

How do you administer imipenem IV?

Imipenem and cilastatin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). When imipenem and cilastatin is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour every 6 or 8 hours.

Is imipenem soluble in water?

Product Info

Cas No.	74431-23-5
Formula Wt.	317.36
Melting Point	106-111°C
Solubility	Water 10 mg/ml, methanol 5 mg/ml, ethanol 0.2 mg/ml
Appearance	White to off white powder

Can imipenem be given orally?

Absorption and distribution. Imipenem is not absorbed by the oral route. No accumulation of imipenem is reported following multiple dosing with cilastatin. Imipenem and cilastatin are both widely distributed in multiple fluids and tissues.

How do you administer Tienam?

Method of administration TIENAM is to be reconstituted and further diluted (see section 6.2, 6.3 and 6.6) prior to administration. Each dose of ≤500 mg/500 mg should be given by intravenous infusion over 20 to 30 minutes. Each dose >500 mg/500 mg should be infused over 40 to 60 minutes.

What does Vanc cover?

Vancomycin, a useful bactericidal antibiotic for selective clinical infections, is the therapy of choice for serious staphylococcal infections when the penicillins and cephalosporins cannot be used. The antibacterial spectrum of vancomycin also covers other gram-positive cocci and bacteria and gram-negative cocci.

How much sodium is in tienam I.V 250?

TIENAM I.V. is buffered with sodium bicarbonate to provide solutions in the pH range of 6.5 to 8.5. There is no significant change in pH when solutions are prepared and used as directed. TIENAM I.V. 250 contains 18.8 mg of sodium (0.8 mEq) and TIENAM I.V. 500 contains 37.5 mg of sodium (1.6 mEq).

What are the components of tienam intravenously infusion?

TIENAM consists of two components: (1) imipenem, the first of a new class of beta-lactam antibiotics, the thienamycins; and (2) cilastatin sodium, a specific enzyme inhibitor that blocks the metabolism of imipenem in the kidney, and substantially increases the concentration of intact imipenem in the urinary tract.

How long does it take to infuse tienam?

In infections due to less susceptible organisms, the daily dosage of TIENAM I.V. may be increased to a maximum of 4 g/day or 50 mg/kg/day, whichever is lower. Each dose of ≤ 500 mg of TIENAM I.V. should be given by intravenous infusion over 20 to 30 minutes. Each dose > 500 mg should be infused over 40 to 60 minutes.

How much cilastatin is in tienam I.V.?

RECONSTITUTION, INTRAVENOUS SOLUTION TIENAM I.V. for intravenous infusion is supplied as a sterile powder in vials containing 250 mg imipenem equivalent and 250 mg cilastatin equivalent or 500 mg imipenem equivalent and 500 mg cilastatin equivalent.