Is IGF-1 bad for diabetics?

IGF-I has an almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycemic response. Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.

Does IGF-1 increase blood sugar?

IGF-I leads to an increase in peripheral glucose uptake and a decreased production of hepatic glucose causing better insulin sensitivity (2,23). Furthermore, low IGF-I serum concentrations were related to a higher anthropometric status, which in turn is related to insulin resistance.

What foods increase insulin-like growth factor?

The following foods/nutrients increased IGF-1 levels in humans:

• protein derived from milk, fish and poultry, but not red meat (Giovannucci and coworkers, 2003)
• protein derived from red meat, fish, seafood and zinc (Larsson and coworkers, 2005)

Does IGF-1 cause hypoglycemia?

Due to its insulin-like action, the most common side-effect to exogenous IGF-1 is hypoglycemia, which occurs in a dose-dependent manner [27]. Insulin-like growth factor 1 (IGF-1) receptor α is overexpressed in pancreatic islets in nesidioblastosis and administration of recombinant IGF-1 causes hypoglycemia [27], [28].

Does fasting increase IGF-1?

Fasting caused an increase in serum GH levels, no significant change in serum GHBP levels, and a decrease in serum IGF-1 levels. In the growth plate, both GH receptor mRNA levels and IGF-1 mRNA levels were increased by fasting.

What stimulates IGF?

IGF-1 is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin.

What is the difference between insulin and insulin like growth factor?

Insulin binds with high affinity to the IR-A or to IR-B but has low affinity for IGF-1R, while insulin has little or no binding to the hybrid receptor. IGF-1 has high affinity for the IGF-1R and to the hybrid receptors.

Does IGF-1 make you lose weight?

Greater weight loss was associated with an increase in IGF-1 and the IGF-1/IGFBP-3 molar ratio among women randomized to diet alone (Table 2), while we observed an inverse trend greater between weight loss and IGFBP-3 in the diet + exercise group.

Is there a link between IGF 1 and diabetes?

Summary: IGF-1 acts similarly to insulin and may be effective against diabetes. It’s long been argued that low IGF-1 increases diabetes risk, but some studies suggest the opposite. More research is needed to explain its role in diabetes.

Can a high IGF-1 level cause weight loss?

Summary: Observational studies have linked low IGF-1 levels with high body mass index. Therefore, increasing IGF-1 levels could, theoretically, promote weight loss, but much more research is needed to support this. Just as IGF-1 helps key cells reproduce and survive, it also promotes growth and survival in unhealthy cells.

What foods can increase the level of IGF-1?

Foods and Nutrients that May Increase IGF-1 1 Carbohydrates. High carbohydrate diets increase insulin activity and may therefore increase IGF-1, which acts a lot like insulin. 2 Dairy. Large observational studies have found higher IGF-1 levels in those who consumed more dairy products ( 43, 44 ). 3 Magnesium. 4 Zinc. 5 Selenium.

What is the effect of IGF-1 on protein metabolism?

They studied the effect of IGF-1 on protein metabolism, IGF-1’s ability to stop the protein-wasting caused by glucocorticosteroid drugs like prednisone, and the effect IGF-1 has on insulin and glucose metabolism.