Are MDA MB 435 cells HER2 positive?
Are MDA MB 435 cells HER2 positive?
Interestingly, the two cell lines used in the initial cell-line studies of BRMS1 were both ER, PR negative; and MDA-MB-435 was HER2 positive in the current study.
What are bt474 cells?
A human breast tumor cell line (BT-474) that supports mouse mammary tumor virus replication. In Vitro 15: 723-729, 1979. PubMed: 94035. Littlewood-Evans AJ, et al. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.
Does MCF 7 express HER2?
MCF-7 sub-lines demonstrate a wide divergence in the relative expression of ER, PR and HER2. The proportion of the dominant phenotype may be maintained by the growth conditions; the predominance of the ER-positive phenotype could be maintained by the presence of small amounts of estrogen in the fetal bovine serum.
Are MCF-7 cells triple negative?
MCF7 and MDA-MB-231 cells represent a striking example in that they are both invasive ductal/breast carcinoma cells, yet they have many phenotypic/genotypic differences: MCF7 are hormone dependent (both estrogen and progesterone receptor positive—ER and PR), while MDA-MB-231 are triple negative.
Is MCF-7 triple negative?
MDA-MB-231 is triple negative breast cancer cell lines and they are about 15% to 20% of all breast cancer cases and hard to treat them. Need more research for discovery of new drugs or compounds. MCF-7 is estrogen receptor positive breast cancer cell lines and effective treatments drugs are available.
Is Herceptin chemo or immunotherapy?
Herceptin is an intravenous drug that is part of a chemotherapy regimen that is used to prevent recurrence of breast cancer, and for the treatment breast cancer that has spread beyond the breast (metastasized). It belongs to a class of drugs called monoclonal antibodies.
Is MCF7 triple positive?
Are MCF10A triple-negative?
Cell Culture. Culture conditions have been described previously [11]; MCF-7, MCF10A, SKBr3, and MDA-MB-231 were purchased from the American Type Culture Collection (ATCC). MDA-MB-231 cells are characterized as triple-negative/basal-B mammary carcinoma and SKBr3 are HER2+ mammary carcinoma.
