How do you administer IV CEREBYX?
How do you administer IV CEREBYX?
2.2 Preparation. Prior to intravenous (IV) infusion, dilute CEREBYX in 5% Dextrose Injection or 0.9% Sodium Chloride Injection to a concentration ranging from 1.5 to 25 mg PE/mL. The maximum concentration of CEREBYX in any solution should be 25 mg PE/mL.
How fast can phenytoin be given IV?
In adults, intravenous administration should not exceed a rate of 50mg per minute. In neonates, phenytoin should be administered at a rate of 1 – 3mg/kg/min. Hypotension usually occurs with rapid administration of phenytoin by the intravenous route.
Is Fosphenytoin only IV?
Intravenous: When fosphenytoin is administered by IV infusion, maximum plasma fosphenytoin concentrations are achieved at the end of the infusion. Fosphenytoin has a half-life of approximately 15 minutes. Intramuscular: Fosphenytoin is completely bioavailable following IM administration of fosphenytoin.
What are the adverse effects of infusing Fosphenytoin too rapidly?
The following serious adverse reactions are described elsewhere in the labeling: Cardiovascular Risk Associated with Rapid Infusion [see WARNINGS AND PRECAUTIONS]…Common side effects may include:
- dizziness, drowsiness;
- unusual or involuntary eye movements;
- vomiting;
- itching; or.
- problems with balance or muscle movement.
When do you hold phenytoin?
Therapeutic Drug Monitoring of Phenytoin 2–4 hours after an IV dose or 12–24 hours after an oral dose or according to clinical response. Daily monitoring may be necessary until control is achieved and concentrations stabilise.
What is purple glove syndrome?
Introduction. Purple glove syndrome (PGS) is a rare complication of intravenous phenytoin use. It typically presents with pain, edema, and discoloration at the injection site that spreads to the distal limb. Treatment is supportive, and most cases resolve within days to weeks.
