What is the half-life of coagulation factors?

Half-lives of these clotting factors are as follows: Factor II – 60 hours, VII – 4 to 6 hours, IX – 24 hours, and X – 48 to 72 hours. The half-lives of proteins C and S are approximately 8 hours and 30 hours, respectively.

What are the 13 blood clotting factors?

The following are coagulation factors and their common names:

• Factor I – fibrinogen.
• Factor II – prothrombin.
• Factor III – tissue thromboplastin (tissue factor)
• Factor IV – ionized calcium ( Ca++ )
• Factor V – labile factor or proaccelerin.
• Factor VI – unassigned.
• Factor VII – stable factor or proconvertin.

Which coagulation factor has longest half-life?

Depletion of both factor X and factor II (prothrombin) is important for clinical efficacy, and factor II has the longest half-life of the vitamin K-dependent factors (approximately three days) [3,4].

Which coagulation factor has the shortest lifespan?

Description. Factor VII circulates as a single-chain zymogen with molecular weight of about 50,000 daltons. It has the shortest half-life of the procoagulant factors, approximately 3-6 hours. The human factor VII gene is located on chromosome 13, very close to the gene for factor X.

Which factor is responsible for blood clotting?

Blood clotting factors Thrombin converts fibrinogen, a blood clotting factor that is normally dissolved in blood, into long strands of fibrin that radiate from the clumped platelets and form a net that entraps more platelets and blood cells.

What is the half-life of Factor 8?

Factor VIII half-life was measured in 42 patients and ranged from 7.4–20.4 hours, with a median of 11.8 hours.

Which cation is responsible for blood clotting?

CLOTTING FACTORS (COAGULATION PROTEINS) These proteins undergo a post translational modification (vitamin K dependent ϒ carboxylation of glutamic acid residues) which enables them to bind calcium and other divalent cations and participate in clotting cascade.

Is Factor 5 a bleeding disorder?

Factor V deficiency is an inherited bleeding disorder that prevents blood clots from forming properly. This disorder is caused by mutations in the F5 gene , which leads to a deficiency of a protein called coagulation factor V.