Is efavirenz a protease inhibitor?

One group of drugs that efavirenz affects is protease inhibitors, which are used for HIV/AIDS. Efavirenz will lower the blood levels of most protease inhibitors, including amprenavir, atazanavir, and indinavir.

What is the mechanism of action of efavirenz?

Mechanism of Action: NNRTIs bind noncompetitively to an active site of the reverse transcriptase molecule. Reverse transcriptase directs the polymerization of DNA from viral RNA. The NNRTIs inhibit this polymerization by altering the position of critical amino acids within the catalytic site.

What is efavirenz used for?

Efavirenz is an antiretroviral medicine that fights human immunodeficiency virus (HIV-1) infection by reducing the amount of the virus in blood. It is used by adults, adolescents and children 3 months of age and older and weighing at least 3.5 kg.

What is the side effect of efavirenz?

Other possible side effects of efavirenz include: Nervous system symptoms, including dizziness, trouble sleeping, unusual dreams, trouble concentrating, drowsiness, and lack of coordination or difficulty with balance. Seizures, which are more likely to happen if you have had seizures in the past.

How much does efavirenz cost?

The cost for efavirenz oral tablet 600 mg is around $636 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

What is the generic name for Sustiva?

Sustiva (Generic: Efavirenz) HIV Drug Facts, Side Effects & Dosage.

How is efavirenz excreted?

Excretion: 14% to 34% is excreted in urine (less than 1% is excreted unchanged), and 16% to 61% is excreted in feces. Terminal elimination half-life is 52 to 76 hours.

Who should not take efavirenz?

Do not use efavirenz if you are pregnant. It could harm the unborn baby or cause birth defects. Use 2 forms of birth control, including a barrier form (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy while you are using efavirenz and for at least 12 weeks after your last dose.

Why efavirenz is taken at night?

Efavirenz is dosed once daily, and is generally administered in the evening owing to its central nervous system side-effects.

Why is efavirenz taken at night?

When should efavirenz be taken?

It is usually taken once a day with plenty of water on an empty stomach (at least 1 hour before or 2 hours after a meal). Take efavirenz at around the same time every day. Taking efavirenz at bedtime may make certain side effects less bothersome.

What kind of Medicine is efavirenz used for?

Efavirenz is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Efavirenz is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

How old do you have to be to take efavirenz?

Efavirenz is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Efavirenz is for adults and children who are at least 3 months old and weigh at least 8 pounds. Efavirenz is not a cure for HIV or AIDS. Efavirenz may also be used for purposes not listed in this medication guide.

What are the side effects of efavirenz at steady state?

Likewise, efavirenz may alter plasma concentrations of drugs metabolized by CYP3A or CYP2B6. The most prominent effect of efavirenz at steady-state is induction of CYP3A and CYP2B6 [ see Dosage and Administration (2.2) and Drug Interactions (7.1) ].

Are there any drug interactions with efavirenz?

Coadministration of efavirenz can alter the concentrations of other drugs and other drugs may alter the concentrations of efavirenz. The potential for drug-drug interactions should be considered before and during therapy. ( 7) Lactation: Breastfeeding not recommended. (8.2)